Compton Creek is a major tributary of the Los Angeles River in and surrounding Compton in Los Angeles County, California. The stream drains a watershed of 42.1 square miles (109 km2). and is the last major tributary to enter the Los Angeles River before it reaches the Pacific Ocean.

The stream begins just east of South Main Street between 107th and 108th Streets in Los Angeles. Compton Creek passes through Willowbrook and runs 8.5 miles (13.7 km) in total. Most of its route is encased in a concrete flood control channel. Shortly after it passes under West Greenleaf Boulevard, it changes to an earth-bottom section with riprap banks. Joined near its end by East Compton Creek, the creek ultimately empties into the Los Angeles River just south of Del Amo Boulevard.

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